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What Side Effects Are Normal on GLP-1s, and When Do They Become a Problem

29 Statistical Analysis Primary Outcomes of the Studies Power Calculation For the STEP 1 to STEP 4 trials, the power calculations were based on the randomization ratio, the 5% significance level, the statistical tests chosen for continuous outcomes (t-test on the mean differences assuming equal variances) and binary outcomes (Pearson chi-square test for 2 independent proportions), and permanent discontinuations of 20% (5% for STEP 4), with 60% of those retrieved at week 68 (based on study NN9536 to 4153)

Hemorrhoids: These are swollen veins in the rectum or anus

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It decreases glucagon levels, which also helps to lower blood sugar

The Headline Figures In the 48-week trial, participants receiving the highest dose of retatrutide (12 mg) lost an average of 24.2% of their body weight