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JACC Cardiovasc Imaging

It's classified as a "triple G" or GGG tri-agonist because it targets three key hormone receptors: GLP-1, GIP, and GCG
Weight reduction has been linked to improved CV risk factors and complications, particularly hypertension, ASCVD, HF, AF, pulmonary hypertension, and left ventricular hypertrophy ( 3.2 Effects on hypertension and hyperlipidemia Besides their contribution to weight reduction and glycemic control, GLP-RAs were associated with BP and lipid levels reduction ( Effects on lipid profile were collected as secondary outcomes from several clinical trials

2006 [cited 2021 Dec 28];8:20613

Given the high unmet medical need, limited competition, and established efficacy in narcolepsy, WAKIX is expected to gain strong commercial traction and have an extended market uptake period if approved for PWS
