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19 December 2024: FDA confirms tirzepatide shortage is still over, gives compounders a grace period Eli Lilly strikes Zepbound deal with Ro, amid questions about future of compounded GLP-1s
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But this same long half-life creates an accumulation effect
This is why many clinicians recommend: Gradual dose reductions Close monitoring of hunger and weight trends Adjustments based on real-world response Stopping suddenly is more likely to result in regain than a guided transition
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