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[11] Tirzepatide Once Weekly for the Treatment of Obesity | New England Journal of Medicine. Accessed: Nov

When you activate both, you're hitting appetite from multiple angles

Insulin helps the body use sugar for energy

If you do not experience an immediate reduction in your appetite, do not feel discouraged or assume the treatment is failing

Prevention focuses on slowing weight loss moderately, staying well-hydrated, eating regular small meals, and avoiding prolonged fasting

Second, time-varying confounding due to informative censoring could be present in as-treated analyses, while an intention-to-treat analysis is not susceptible to treatment-related informative censoring