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Other agents such as exenatide have demonstrated efficacy but are not specifically FDA-approved for weight loss indications

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Moreover, because GLP-1R is expressed throughout the body, stimulation with a GLP-1R agonist or indirectly with a DPP-IV inhibitor can have a broad systemic effect on systemic metabolism, which, in turn, ameliorates peripheral and central insulin resistance in AD and MD (Athauda and Foltynie, 2016)

2023 Ludvik B, Giorgino F, Jodar E et al (2021) Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial