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[DOI] [PubMed] [Google Scholar] [158].Fineman MS, Mace KF, Diamant M, Darsow T, Cirincione BB, Booker Porter TK, Kinninger LA, Trautmann ME, Clinical relevance of anti-exenatide antibodies: safety, efficacy and cross-reactivity with long-term treatment, Diabetes, obesity & metabolism, 14 (2012) 546554

In alzheimers disease, 6-month treatment with GLP-1 analog prevents decline of brain glucose metabolism: Randomized, placebo-controlled, double-blind clinical trial

2024) or tirzepatide (Packer et al, 2025a

This may overload the manufacturer and the shortage could be re-designated

However, the long half-life smooths this out over time, reducing steady-state variability to about 33%