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doi: 10.1016/S2213-2600(21)00511-7 [DOI] [PMC free article] [PubMed] [Google Scholar] 2.Global Initiative for Chronic Obstructive Lung Disease (GOLD)

Furthermore, existing studies have shown that opioid dependence can influence the epigenetic landscape, morphological structure, and neurotransmitter secretion in brain regions such as the prefrontal cortex (PFC), Nucleus Accumbens (NAc), and amygdala [8,13,14]