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These mechanisms do not prove benefit, but they explain why the scientific community is increasingly interested in GLP-1 drugs within the context of chronic inflammatory gynecologic disease

Borrell, L

You should be advised to: Report any new neck swelling or changes in voice Monitor for symptoms of thyroid dysfunction (either hypo- or hyperthyroidism) Maintain consistent timing of levothyroxine administration Keep a record of weight changes Report severe or persistent gastrointestinal symptoms Stay well-hydrated, especially if experiencing nausea, vomiting or diarrhoea Medication adherence to both levothyroxine and GLP-1 therapy is essential for optimal outcomes

But its not clear how well it works in humans

CLINICAL TRIAL EVIDENCE FOR DUAL GLP-1/GLUCAGON RAs AND TRIPLE AGONISTS IN MASH Survodutide Survodutide, a weekly dual GLP-1/GCG agonist, was assessed in a phase 2 dose-finding trial (NCT04771273) including 293 individuals with histologically confirmed MASH and fibrosis stages F1-F3 [46]

There is going to be growing pressure to cover obesity drugs, so this is not an issue that the incoming administration can easily just sidestep, Larry Levitt, EVP for health policy at KFF, told Healthcare Brew