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12,16 however, there is a lack of data comparing these GLP-1 RA outcomes versus other glucose lowering therapies

Retatrutides additional glucagon receptor activity may make it more relevant in studies involving broader metabolic signaling pathways

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Our biopsychosocial approach predicts that there may be an initial decreased desire from these medications, due to a direct effect on the 5-HT pathway, GI side effects, and other factors compounding an already low baseline sexual desire based on body image