can you stop glp 1 GLP-1s & Keep Weight Off? A Guide to Success can you stop glp 1

The beauty of AOD-9604 is what it does not do

Almost all patients lose between 10% and 20% of their body weight

The study 15 on cocaine use disorder only observed the effect of acute treatment with exenatide in a small set of patients, and thus more evidence is needed to understand the role of GLP-1 analogs in cocaine use disorder

Furthermore, while the further truncation of GLP-1 to remove the first eight residues resulted in a peptide with 370-fold reduced affinity [GLP-1(15-36)amide], Ex4(9-39) retains high affinity for GLP-1R

Side Effects: What to Expect GI side effects dominate the profile

nausea decreases with ongoing usage a steady weight loss occurs in some patients over 2 years (may be related to nausea & CNS-mediated loss of appetite) there is an increased risk of hypoglycemia when exenatide is used with a sulfonylurea The dose of the sulfonylurea may need to be reduced if hypoglycemia occurs when combined with exenatide Most serious : rare & sometimes fatal necrotizing or hemorrhagic pancreatitis When initiating patients on Byetta, watch for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back, which may or may not be accompanied by vomiting)