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The study did, however, also highlighted several negative side effects, including constipation (118 occurrences), diarrhea (100 events), and abdominal pain (41 events per 1,000) (48)

Finally, given that GLP-1 agonists have become mainstream and popular in the media, it may just be that reporting of adverse events is higher relative to other drugs [26]

Agonists of the incretin glucagon-like peptide-1 (GLP-1) have established efficacy for glycaemic reduction, weight loss, and cardiovascular risk modification

Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax

Moreover, compounded medications undergo rigorous quality control measures to uphold safety, efficacy, and consistency

Clinicians say its an administrative challenge because insurers have inconsistent coverage criteria, require time-intensive documentation, and frequently deny coverage