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Appropriate reasons to discuss discontinuation include achieving your weight loss goals and wanting to attempt weight maintenance without medication, experiencing intolerable side effects that don't improve with dose adjustment or supportive management, financial constraints that make continued treatment unsustainable, planning pregnancy (semaglutide is not recommended during pregnancy and should be discontinued at least two months before conception), or developing contraindications to continued use
Doctors say theyre most appropriate for people with Type 2 diabetes, and adults with a BMI over 30 or 27 with a condition, including people whove had a heart attack or stroke, peripheral vascular disease, and for sleep apnea, Apovian said

At times, frustration or even a loss of quality of life from the reduced pleasure obtained from food (or other aspects of life) may result in changes in affect and potentially medication discontinuation [148]
