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If considered for the indication of obesity in HFrEF, caution and close monitoring are warranted.
In this scenario, preventing excess glucagon secretion helps lower blood sugar levels
The GLP-1 receptor agonist albiglutide was also approved, but has been withdrawn for commercial reasons
doi: 10.1007/s10787-023-01239-4, 47
Additionally, retatrutide lowered blood glucose and insulin levels, suggesting that retatrutide enhanced insulin sensitivity
A randomized Phase I study of the safety, tolerability, pharmacokinetics and pharmacodynamics of BI 456906, a dual glucagon receptor/glucagon-like peptide-1 receptor agonist, in healthy Japanese men with overweight/obesity
