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Thyroid hormone treatment often improves symptoms but has limited impact on fat loss

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The main challenge during the initial development of GLP-1 receptor agonists was the very short half-life in the circulation of 2 minutes [34]

The hypothesis underlying this mechanism was that the hypoglycemic effects of GLP-1 could firstly counteract the hyperglycemic potential of glucagon, while the anorectic effect of central GLP-1 agonism would complement glucagons own anorectic, lipolytic, and thermogenic properties to maximize body weight loss