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Given the increasing evidence of alternative receptor-independent sources of cAMP (from intracellular sAC) (29, 30), we hypothesized that GLP-1(2836) mediates its GLP-1Rindependent effects through sAC

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In PIONEER 7, flexibly dosed oral semaglutide 3, 7 and 14 mg once daily were compared with sitagliptin 100 mg once daily in patients receiving 12 of the following oral glucose-lowering medications: metformin, thiazolidinedione, sulphonylurea and SGLT2i [10]

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