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29 Intriguingly, the intracellular consequences of tirzepatide binding at the GLP-1R seem to be peculiarly biased towards cyclic adenosine monophosphate generation, at the expense of -arrestin recruitment

We used R software (version 3.2.2, Free Software Foundation, Inc, Boston, MA), SAS (version 9.2, SAS Inc., Cary, NC), and Stata/MP (version 16, StataCorp, College Station, TX)

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Finally, participants were filtered on relatedness such that no two people shared more than 700 cM identity by descent 37 , which corresponds approximately to the minimal expected sharing between first cousins in an outbred population, resulting in a final GWAS sample size of 15,237