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Description

Firstly, the sample size of this study is relatively small, and the study has a comparatively high drop rate

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Among the most frequent adverse effects are: vomiting, nausea, diarrhea, hypoglycemia in case of use with oral diabetes medications other than sulfonylureas or insulin, gastritis, stomach pain, fatigue, constipation, dizziness, retinopathy

Abbreviations: Fmoc: 9-fluorenylmethoxycarbonyl Boc: Tert-butoxycarbonyl DCM: dichloromethane DMF: N, N-dimethyl form amide DIC: N, N -diisopropyl carbodiimide DIE A: Diisopropylethylamine HOBt: N-hydroxy benzotriazole CTC resin: 2-Chlorotrityl chloride resin SPPS: Solid phase peptide synthesis TFA: Trifluoroacetic acid TIPS: Triisopropyl silane EDC.HC1: 1 -(dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride DTT: Dithiothreitol EDT: 1 ,2-Ethanedithiol Detailed Description of the Invention The present invention provides an improved process for the preparation of Semaglutide by making appropriate fragments on solid support, followed by condensing these fragments using solution phase approach with higher yields and purity