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Description
The mechanism involves direct action on GLP-1 receptors in the liver

And there are concerns that patients regain weight quickly if and when they stop taking the drug

It reflects the biological reality that the medication was managing a chronic condition, and removing it allows the condition to reassert itself

The process doesnt stop there, however

Most providers recommend starting the new medication at the same time you would have taken your next scheduled dose of the previous medication

The strategies for when tirzepatide results plateau translate well to maintenance challenges, as many of the underlying principles are the same