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Exercise-Induced GLP-1 Secretion Ninety minutes of exercise in mice induces a 2.5-fold increase in plasma active GLP-1, mediated by skeletal-muscle-derived IL-6, as shown by abolishing exercise-induced active GLP-1 levels in Il6 / mice and by treating wild-type mice with an antibody to IL-6 (Ellingsgaard et al., 2011)