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This method is based on spontaneous isopeptide bonding between two protein parts derived from Gram-positive bacteria, achieving high conjugation efficiencies (up to 90%) but requiring fusion of large moieties ( e.g ., ~ 12 kDa Catcher), which can introduce challenges similar to genetic fusion

H., Canto, C., Wanders, R

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Moreover, GLP-1 RAs contribute to the management of hypertension by lowering BP and reducing variability