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Most Common Early Side Effects in the First Two Weeks Nausea ranks as the most frequently reported side effect during the first 14 days, affecting roughly 25 to 40 percent of patients in clinical trials

Experientia (1986) 42(5):5479

Week 12 typically brings 25 pounds (mostly water and glycogen), weeks 38 often deliver 12 pounds per week as your body adapts to reduced calorie intake, and weeks 912 may show a slight slowdown as your metabolism adjusts

Abdominal Pain : Pain or discomfort in the stomach area is also reported

Weight loss accelerates in months two and three once the dose reaches therapeutic levels

NeuroImmune Pharmacol