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Mutations in these genes are linked to monogenic obesity, characterized by early onset weight gain and hyperphagia

Naltrexone-bupropion (Contrave) Contrave combines an opioid antagonist (naltrexone) with an antidepressant (bupropion)

Its primary role is to regulate blood sugar levels by stimulating insulin release and inhibiting glucagon

The left side of the figure describes small molecule GLP-1 receptor agonists currently in the process of drug development

Endocrinology (2005) 146(8):355866

Introduction Glucagon-like peptide 1 receptor agonists (GLP1-RA) have been widely used as therapeutic agents for the management of type 2 diabetes