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Description
we reported the characteristics of the included trials in Table 1, and the excluded studies in Table S2
Quality assessment The quality of included studies was assessed using the Cochrane risk-of-bias tool
Pathway blockade to reduce muscle mass loss in GLP-1 agonists use
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Glucagon-like peptide 1 (GLP-1) Mol
Clinical trials show tirzepatide produces 22.5% average weight loss compared to semaglutides 14.9%, likely because activating both incretin pathways provides more comprehensive metabolic regulation than activating one pathway alone
