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And a few operate through business models that raise questions about whether the product itself is the priority, or whether recruitment is the real revenue engine
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Starting at low doses and slowly increasing over weeks to months significantly improves tolerability

Abstract Metformin is an effective agent with a good safety profile that is widely used as a first-line treatment for type 2 diabetes, yet its mechanisms of action and variability in terms of efficacy and side effects remain poorly understood

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