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Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents

Daewoong Pharmaceutical, with the support of Daewoong Therapeutics, a subsidiary dedicated to R&D, has completed non-clinical trials and gathered data on a microneedle patch containing the GLP-1 analogue 'Semaglutide' using its own platform, 'Clopharm'

Treatment was associated with fibrosis improvement by at least one stage with no worsening in non-alcoholic fatty liver disease (NAFLD) activity score in 25% of resmetirom recipients versus just under 15% in the placebo group

Since May 2023, the FDA has listed Ozempic and Wegovy on their drug shortages list

These figures position retatrutide as the research compound with the most extensive triple-axis metabolic effect currently under study
