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Wegovy is a prescription medication containing semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist licensed for chronic weight management in adults with obesity or overweight with weight-related comorbidities, as per NICE Technology Appraisal 875

These agents produce multiple beneficial effects, which include anti-inflammatory action along with anti-atherogenic effects, endothelial-protective benefits, and cardioprotective actions to minimize major adverse cardiovascular events (MACEs)

Dosage requirements : Treatment typically starts at a lower dose and escalates to therapeutic levels over several weeks

The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow chart, as shown in Figure 1, was used to visualize the numerical outputs from reviews and the inclusion decision process

PLoS One (2014) 9(5):e97554.10.1371/journal.pone.0097554 68 El-SaharAESafarMMZakiHFAttiaASAin-ShokaAA

[DOI] [PMC free article] [PubMed] [Google Scholar] [56].Cabou C, Campistron G, Marsollier N, Leloup C, Cruciani-Guglielmacci C, Penicaud L, Drucker DJ, Magnan C, Burcelin R