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& Lipska, K

Among its findings: Protandim increased the median lifespan of male mice by 7% which the paper characterized as a small but statistically significant change that wasnt seen in female mice

Finally, GLP-1 RAs may have a role in treating nonalcoholic steatohepatitis through lowering hepatic inflammation, steatosis and fibrosis, although the mechanistic basis for this is yet to be determined [128]

But more likely, that 7% consumes a significantly larger number of calories than the average

10.1038/s41574-021-00498-x Nat

Histone deacetylases (HDAC2), a member of the HDAC family, is correlated with insulin signaling components in postsynaptic glutamatergic neurons of the adult mouse hippocampus, and hyperactivity of the HDAC system (including HDAC2) may result in the suppression of the insulin signaling system and consequent disruption of synaptic plasticity in type 2 diabetes