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A further subgroup analysis was performed only for body weight parameters (that is, TBWL%, waist circumference, BMI and proportion of patients achieving at least 5%, 10%, 15%, 20% and 25% of body weight reduction) in RCTs specifically designed for body weight reduction

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These results suggest that the gut microbiota, the gut microbiota-derived NMN, and the intestinal NAMPTNAD + SIRT axis collaborate to regulate intestinal homeostasis and systemic metabolic functions (Figure

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