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Early initiation of HRT near menopause has shown cognitive and metabolic benefits, while transdermal estrogen is preferred for women with cardiovascular risk due to its safer profile

24 Assuming an estimated dropout rate of 20%, 36 participants were planned to be randomized per group

These include tooth decay, sensitivity, enamel erosion, dry mouth, inflamed gums, and in more serious cases, cracked or loose teeth

Individuals may find themselves eating in response to these mental cues rather than physiological hunger, leading to excess caloric intake and weight gain over time

These investigations demonstrate that GLP-1RAs have the potential to influence important pathways linked to the development of IBD

In December 2025, Eli Lilly released Phase 3 clinical trial results showing that retatrutide produced an average weight loss of 28.7% of body weight at 68 weeks