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The implications from this body of evidence are important as patients and clinicians consider the risk and benefits of GLP-1 RA

The exact aetiology remains unclear, but UC is thought to result from an inappropriate immune response to intestinal microbiota in genetically susceptible individuals

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49,58 Considering that GLP-1RAs beneficial effects on MASLD may relate to improving systemic metabolism rather than direct hepatic effects, comparing hepatic benefits among different antidiabetic medications is meaningful