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Up to 55% of patients developed anti-drug antibodies [65], which were associated with systemic allergic reactions in approximately 5% of cases and injection-site hypersensitivity, including anaphylaxis, which necessitated early trial termination [66, 67]

10.1038/srep26859 [DOI] [PMC free article] [PubMed] [Google Scholar] 88.Gerstein HC, Hart R, Colhoun HM, Diaz R, Lakshmanan M, Botros FT, et al

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[10] Day JW, et al

By combining GLP-1 receptor agonists with other agents, such as GIP or glucagon receptor agonists, researchers are achieving greater weight loss, improved glycemic control, and broader metabolic benefits

The transformative breakthroughs in GLP-1 research recognized by the 2024 Lasker~DeBakey award