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Concurrently, in insulin-resistant states, increased circulating levels of insulin stimulate hepatic lipogenic enzymes and increase de novo hepatic lipogenesis, exacerbating hepatic steatosis, inflammation, and fibrosis [6, 12]

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On the basis of these observations, we can conclude that leptin neutralizing antibody is well tolerated and can be combined with any weight loss therapies to induce higher degrees of weight reduction

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