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Unlike more complex multi-biomarker frameworks such as the Core Obesity Model (COM) ( The model followed a hypothetical cohort of 1,000 adults whose baseline characteristics were aligned with those of the STEP 8 clinical trial population ( The model was run over a 40-year time horizon to approximate a lifetime perspective, with 3-month cycles in the first year (to capture treatment response and discontinuation) and annual cycles thereafter

Regular follow-up during dose titration and periodically thereafter allows optimization of treatment while maintaining patient safety and well-being throughout the weight loss journey

Conclusions A pre-existing reduction in leptin sensitivity determines the susceptibility to develop excessive DIO after fcHFHS diet exposure

It is primarily used to manage type 2 diabetes and has also been shown to facilitate significant weight loss in individuals with obesity

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