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To determine how GLP-1R activation alters calcium dynamics in VTA dopamine neurons during cocaine seeking, rats were pretreated with vehicle or exendin-4 (2.0 g/kg, i.p.) prior to a cocaine priming-induced reinstatement test session (Fig 6A)

Practical Application Start with vegetables and protein (stimulates early GLP-1 release) Follow with complex carbohydrates (sustains GLP-1 secretion) End with fruit or small dessert (if desired) Protein: 25-30% of calories Fiber-rich carbohydrates: 40-45% of calories Healthy fats: 25-30% of calories Breakfast: Greek yogurt with berries, ground flaxseed, and almonds Lunch: Grilled salmon over mixed greens with quinoa and olive oil dressing Dinner: Chicken breast with roasted vegetables and sweet potato This macronutrient distribution provides the protein and fiber necessary for GLP-1 stimulation while supporting stable blood sugar levels already within normal range

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Eat bland, low-fat foods if you feel nauseous