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M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7
When the researchers treated duodenal NET spheroids (which expressed GLP-1 receptors) with semaglutide in the lab, those cells activated a growth pathway and grew more over 2 weeks
This popularity translated into drug shortages when supply couldnt match demand
Sounds like a winning combination, doesnt it
Same dual GIP and GLP-1 receptor activity
