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Further evidence supporting the hypothesis that decreased NTS PPG expression produces a hunger-like behavioral state that promotes/facilitates drug seeking comes from a previous study showing that decreased PPG expression in the NTS produces hyperphagia and exacerbates high fat diet-induced obesity [102]

Incretins play an important role in glucose homeostasis and appetite control [18]

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The hallmarks of oxidative stress, including malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OHdG), are often elevated in chronic pain animal models, highlighting the pathophysiological significance of oxidative damage [26]

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