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Patients experiencing the greatest long-term success prioritize protein intake (2535g per meal) to preserve lean muscle during weight loss, incorporate whole grains and fiber to support satiety, and stay hydrated as the medication can increase feelings of fullness

Metformin commonly causes mild gastrointestinal upset, while semaglutide may produce nausea, vomiting, and appetite suppression

A patient with certain FTO or MC4R variants may experience stronger appetite suppression at lower semaglutide doses, while others may require higher doses to achieve equivalent results

Adherence to weekly or twice-weekly injection schedules is essential

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Thanks, Lorie F