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The theoretical concern based on animal data has not materialised in clinical practice

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DeFronzo RA (2009) From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus
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Introduction to GLP-1 Physiology The primary, most well-studied mechanism of GLP-1 activity on glycogen synthesis lies in its incretin abilities to increase pancreatic beta-cell insulin secretion in postprandial states [66]

What got me here (perimenopause perimenopaus-ing) As estrogen and progesterone fluctuate, and then begin their gradual decline, several metabolic changes occur: Insulin becomes less efficient Estrogen is insulin-sensitizing