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[16] In some cases, switching to an alternative agent with different pharmacokinetic properties or discontinuing therapy may be necessary if symptoms significantly impair quality of life or pose health risks

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Similarly, the evaluation of gastrointestinal symptoms such as nausea, vomiting, and diarrhea, which occur frequently with GLP-1RAs (42) and have a major influence on the adherence to such treatment over time, have often been assessed in clinical trials solely via participant self-report, which is known to be unrelaible (eg, symptoms may not be volunteered due to embarrassment or poor recall) (43, 44)