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Sources & References 1RPEP-01190Teichman, Sam L et al

Patients with a history of pancreatitis should use caution, and those with severe gastrointestinal disease (such as gastroparesis) may not tolerate the medication well due to its effects on gastric emptying

For instance, older patients are susceptible to sarcopenia and fragility: Losing additional LBM due to pharmacotherapy is counterproductive to functional independence

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The "frozen" look is a fear, and a misconception

It also acts on the brain to reduce appetite and food intake, leading to weight loss