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Conclusions Patients with T2D starting tirzepatide had greater HbA1c and weight reductions at 12 months post-initiation than those on injectable semaglutide, regardless of previous GLP-1 RA use, consistent with previous clinical trial results.

Semaglutide is FDA approved, and shown to be significantly effective for weight loss in over weight individuals.

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Congress has introduced the SAFE Drugs Act of 2025, a bill that would significantly expand federal oversight of compounding pharmacies and outsourcing facilities, with particular focus on GLP-1 drugs and telehealth distribution models