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Clinical trials investigating GLP-1 receptor agonists for reducing alcohol consumption have used established dosing regimens

While real-world results may be slightly less, the improvements go beyond weight: Lower blood sugar, blood pressure, and triglycerides Reduced waist circumference and sleep apnea symptoms Better health-related quality of life Fewer major cardiovascular events Reduced progression of fatty liver disease and chronic kidney diseaseeven in the absence of weight loss (Mozaffarian et al., 2025)

This modification extends its half-life, making it suitable for a once-weekly subcutaneous injection formulation [85,86]

Epidemiological evidence demonstrates a strong association between obesity and KOA, highlighting shared pathogenic mechanisms

Despite the small sample size (only 10 patients), the observed benefits suggest that GLP-1RAs could have a therapeutic role in PsA through inflammation reduction, similar to what had been observed in PsO (61)