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The net benefit of GLP-1 receptor agonists in adults with overweight or obesity who do not have diabetes depends on their weight loss target and willingness to accept harms, according to researchers.Although GLP-1 receptor agonists have demonstrated effectiveness in reducing weight loss and risks for other chronic diseases, questions remain over whether the benefits outweigh the harms of the

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The primary end point was acomposite of death from cardiovascular causes, myocardialinfarction (MI), or stroke and was tested for noninferiority (noninferiority margin for the hazard ratio, 1.05)