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Were left wondering, How are GLP-1s causing these effects? asks senior author Marc Montminy, MD, PhD, a biochemist, physiologist, and distinguished professor emeritus at Salk
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10.1007/s00125-001-0719-z 6 AlhadeffA

With GLP-1 therapy, especially when combined with proper resistance training and protein intake , the ratio shifts dramatically toward fat loss while preserving lean mass

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This agent, following its metabolism to 1-methyl-4-phenylpyridinium, is then selectively transported into the DAergic neurons causing cell death by inhibiting mitochondrial complex I
