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When NAD+ is depleted, mitochondrial output falls, and muscle cells become less efficient at producing energy and maintaining their own structure

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Notably, exenatide immediate-release (Byetta) and lixisenatide (Adlyxin, and in Soliqua) do not carry this boxed warning or contraindication

Tirzepatide discontinuation data tells a similar story

For reference, normal poop should look light brown to brown-green and sausage-like, according to the National Association for Continence

[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Newsome PN, Buchholtz K, Cusi K, Linder M, Okanoue T, Ratziu V, Sanyal AJ, Sejling AS, Harrison SA NN9931-4296 Investigators