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Botanicals work through entirely different pathways that do not involve microbial colonization at all

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These drugs were initially approved for the treatment of type 2 diabetes but have recently gained international attention for weight loss and cardiovascular risk reduction in obese patients with or without type II diabetes 4,5

Recent reviews by these agencies have found no evidence of a causal association between GLP-1 receptor agonists and suicidal thoughts or self-harm, though vigilance continues

Treatment duration in older patients should balance weight loss benefits against the risk of excessive lean mass depletion

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