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2008;51(suppl 1):S356

, Hirota, M

Schedule Regular Dental Visits Schedule dental visits every six months at a minimum, and consider adding an extra cleaning or checkup if you start a new medication

Common adverse effects are predominantly gastrointestinal and typically emerge during dose escalation: Nausea (affecting 2050% of users initially) Vomiting and diarrhoea Constipation Abdominal pain and bloating Reduced appetite (therapeutic effect but may be excessive) Fatigue and headache Injection site reactions (redness, swelling or itching) These effects usually diminish over several weeks as the body adjusts

These findings demonstrate that Gipr Syn/ mice are resistant to the weight-lowering effects of mGIPR-Ab, highlighting the crucial role of CNS GIPR for the body weight response to mGIPR-Ab

2.4 Data synthesis The available data from the included studies and their supplementary files were presented comprehensively to synthesize the existing evidence from the selected eligible systematic reviews and meta-analyses