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The STEP 1 extension study showed approximately two-thirds of weight was regained within one year of stopping semaglutide

In my clinical experience, many patients who plateau on semaglutide see renewed progress after transitioning to tirzepatide, although individual results vary and treatment decisions should always be guided by a medical provider

For others, semaglutide is the better fit

These findings support the further investigation of once-weekly dosing of tirzepatide in Japanese individuals with T2D

Dose adjustments may be necessary based on patient response, tolerance, and individual treatment goals, as determined by the patients physician

Retatrutide vs Tirzepatide: Comprehensive Comparison A detailed comparison of Retatrutide and Tirzepatide, covering their receptor pharmacology, weight loss efficacy, side effects, and clinical development as next-generation metabolic peptides