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Nagashima M, Watanabe T, Terasaki M, et al

2 Wilcoxon rank sum test

Here, we report the design and target validation of EP45, a chimeric dual agonist peptide that has the surprising ability to act as an agonist at both the glucagon-like peptide-1 receptor (GLP-1R) and the neuropeptide Y 2 receptor (NPY2R)

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That is the same combination tirzepatide uses, and the same combination Roche's enicepatide and Lilly's investigational retatrutide use (retatrutide adds a third glucagon)

When retatrutide binds the glucagon receptor on cardiac cells, it activates adenylyl cyclase