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In pre-clinical models, we and others have shown that enhancing ER actions in -cells protects survival and function in the face of multiple diabetic insults 2,3,4,5,6,7,8,9,10

A recent study treating ex vivo isolated human bronchi with exendin-4 demonstrated a positive GLP-1R immunostaining pattern in key airway structures, including the epithelium, bronchial cilia, mucous glands, inflammatory cells, and the ASM of medium-sized bronchi (Figure 5A)

Glucagon-like peptide-1 receptor agonist inhibits aeroallergen-induced activation of ILC2 and neutrophilic airway inflammation in obese mice

Researchers found that while there were no significant differences in disease-free survival between those who received GLP-1s and those who did not, there was a significant improvement in overall survival for patients on GLP-1s compared to the control group

Originally developed for managing type 2 diabetes, Semaglutide GLP-1 plays a significant role in regulating appetite, which can support effective weight management